In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 956010-87-0, name is 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 3-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine
Step b) 1H-Pyrazolo[3,4-b]pyridine-3-carbonitrile In 33% strength aqueous ammonia solution (10 ml), 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine (500 mg, 2.67 mmol) is heated in the microwave at 140 C. for 10 min. The mixture is then concentrated under reduced pressure, and the residue is triturated at 70 C. with 100 ml of ethyl acetate and 20 ml of tert-butyl methyl ether. Insoluble components are filtered off with suction in the heat, and the filtrate is concentrated. Drying gives 346 mg (90% of theory) of the title compound as light-beige crystals. 1H-NMR (400 MHz, DMSO-d6): delta=7.47 (dd, J=8.2, 4.5 Hz, 1H), 8.46 (dd, J=8.2, 1.5 Hz, 1H), 8.73 (dd, J=4.5, 1.5 Hz, 1H), 15.02 (br. s, 1H).
The synthetic route of 956010-87-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER HEALTHCARE AG; US2010/4235; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem