Electric Literature of 3430-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3430-22-6, name is 3-Bromo-4-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The apparatus was installed, and 3-bromo-4-methylpyridine (13 g, 0.78 mol), Co0.27CuO3 (0.5 g), water was added to the three-necked flask in turn, and the mixture was stirred, and the oil bath was slowly heated to 90 C.Oxygen is initially introduced to maintain the reaction temperature until no oxygen is absorbed under the secondary reaction conditions.The catalyst was filtered off, then slowly added with a NaOH solution to adjust pH = 4, followed by stirring for 10 minutes.There is solid precipitation,The crude product 3-bromoisonicotinic acid was obtained, which was recrystallized from acetone to give a white powdery solid, which was filtered and dried in vacuo.A final yield of 14 g of 3-bromoisonicotinic acid was obtained.The yield was 90%.
According to the analysis of related databases, 3430-22-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dalian Jindian Biological Technology Co., Ltd.; Jin Feng; (5 pag.)CN109851551; (2019); A;,
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