Adding a certain compound to certain chemical reactions, such as: 1193-71-1, 4,6-Dimethylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1193-71-1, blongs to pyridine-derivatives compound. SDS of cas: 1193-71-1
A solution of step 1 intermediate of example 14 (301 mg, 951 pmol) in thionyl chloride (3 mL) was heated to 70 C for 4 h. The volatiles were removed under reduced pressure and the residude was dissolved in CH2CI2 (14 mL) and NEt3 (254 pL, 1.79 mmol) and 4,6-dimethylpyridine-3-amine (114 mg, 940 pmol) were consecutively added and the mixture was stirred at rt overnight. The volatiles were removed underreduced pressure and the residue was purified by chromatography (lnterchim cartridge 5OSiHP /12 g,EtOAc/Cy) to yield the title compound of example 19 (136 mg, 36%).LC-MS (Method 2): m/z [Mi-H] = 421.1 (MW calc. = 420.80); R = 0.59 mm.1H-NMR (DMSO-d6): 6 = 9.84 (s, 1H), 8.36 (s, 1H), 7.93 (s, IH), 7.73 (s, 1H), 7.17 (s, 1H), 6.85 (s, 1H),3.77 (s, 3H), 2.43 (s, 3H), 2.21 (s, 3H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-71-1, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem