Related Products of 67443-38-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 25 ml single-port round bottom flask were added 2-chloro-3-nitro-5-bromo pyridine (500 mg, 2.11 mmol) and methanol. The solution of sodium methoxide (228 mg, 4.22 mmol) in methanol was added into the flask. The reaction mixture was stirred at room temperature for 48 hours. The reaction was quenched with water and concentrated. The residue was extracted with ethyl acetate, dried with Na2SO4, and filtered to afford product 2-methoxy-3-nitro-5-bromo pyridine as a light yellow solid. [0205] 1HNMR (300 MHz, CDCl3): 8.502 (d, 1H) 8.302 (d, 1H) 4.113 (s, 3H); [0206] M+H: 233, 235
According to the analysis of related databases, 67443-38-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Astar Biotech LLC; Yu, Chunrong; Huang, Yong; US2014/38991; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem