Related Products of 112110-07-3, Adding some certain compound to certain chemical reactions, such as: 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112110-07-3.
To a 5 ml reaction vial was added 2-[4-[2-[(1-methylimidazol-4-yl)amino]pyrimidin-5-yl]phenyl]acetic acid (14, 160 mg, 0.050 mmol) followed by anhydrous NMP (1.5 ml), 5-(trifluoromethyl)pyridin-3-amine (10, 8 mg, 0.05 mmol) and pyridine (80 mul). To the mixture was slowly added propylphosphonic anhydride (50 wt % solution in ethyl acetate, 0.25 ml, 0.42 mmol). The reaction was allowed to stir at room temperature for three hours. Upon completion, the reaction was poured into water and extracted with ethyl acetate. The organic phase was washed with saturated aqueous ammonium chloride and brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed under reduced pressure in the presence of silica. The resulting crude material was purified by silica gel flash column chromatography eluting with 0-15% methanol in dichloromethane. This provided compound P-0167. MS ESI [M+H+]+=452.00.
According to the analysis of related databases, 112110-07-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Plexxikon Inc.; Lin, Jack; Ibrahim, Prabha N.; Albers, Aaron; Buell, John; Guo, Zuojun; Pham, Phuongly; Powers, Hannah; Shi, Songyuan; Spevak, Wayne; Wu, Guoxian; Zhang, Jiazhong; Zhang, Ying; (132 pag.)US2017/267660; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem