Adding a certain compound to certain chemical reactions, such as: 524955-09-7, 3-Chloro-4-(pyridin-2-ylmethoxy)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 3-Chloro-4-(pyridin-2-ylmethoxy)aniline, blongs to pyridine-derivatives compound. Quality Control of 3-Chloro-4-(pyridin-2-ylmethoxy)aniline
Example 74 Production of N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-6-(2-furyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine A mixture of 4-chloro-6-(2-furyl)-5H-pyrrolo[3,2-d] pyrimidine (80 mg), 3-chloro-4- (pyridin-2-ylmethoxy) aniline (94 mg) and 1-methyl-2-pyrrolidinone (2.5 mL) was stirred at 140C for 2 hrs, poured into water (10 mL) and adjusted to pH 8 with saturated aqueous sodium hydrogen carbonate. The mixture was extracted with ethyl acetate (30 mLx2). The organic layers were combined and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography (eluent, hexane:ethyl acetate=1:1 ? 0:1). The object fraction was concentrated under reduced pressure. Chloroform – diisopropyl ether was added to the residue, and the solid was collected by filtration and dried under reduced pressure at 60C to give the title compound (71 mg). 1H-NMR (DMSO-d6) delta 5.27 (2H, s), 6.72 (1H, m), 6.78 (1H, d, J= 1.2 Hz), 7.02 (1H, d, J= 3.3 Hz), 7.26 (1H, d, J= 9.0 Hz), 7.36 (1H, m), 7.53-7.59 (2H, m), 7.81 (1H, d, J= 8.1 Hz), 7.91 (1H, s), 8.21 (1H, d, J= 2.4 Hz), 8.34 (1H, s), 8.59 (1H, d, J= 5.1 Hz), 9.19 (1H, br s), 11.62 (1H, br s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,524955-09-7, 3-Chloro-4-(pyridin-2-ylmethoxy)aniline, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1752457; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem