Adding a certain compound to certain chemical reactions, such as: 524955-09-7, 3-Chloro-4-(pyridin-2-ylmethoxy)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 524955-09-7, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Chloro-4-(pyridin-2-ylmethoxy)aniline
A mixture of N-(4-chloro-3-cyano-7-(2-methoxyethoxy)quinolin-6-yl)acetamide (6.3g, 0.0197 mol, 1.00 equiv), 3-chloro-4-(2-pyridylmethoxy)aniline (4.7g, 0.0201mol, 1.00 equiv), methanesulfonic acid (0.7ml, 0.0108 mol) and ethanol (150 ml) was stirred under refluxed for 6 hours and then 0.6N hydrogen chloride (300 ml, 0.18 mol) was added. The mixture was heated to 80 0C for 19 hours, and then cooled to 0 0C to form precipitate. The precipitated solids were filtered and then added to a solution of IN potassium carbonate (100ml, O.lmol) in methanol (150ml) and then the mixture was stirred for 3 hours. The resulting mixture was filtered, washed with 1 : 1 methano I/water (300ml) and dried to give product 6.4g. MS (ESI) m/z: 475 (M+l).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,524955-09-7, its application will become more common.
Reference:
Patent; MEDOLUTION LIMITED; ZHANG, Dawei; WO2010/151710; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem