According to the analysis of related databases, 582325-22-2, the application of this compound in the production field has become more and more popular.
Related Products of 582325-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 582325-22-2, name is 6-(3-Fluorophenyl)nicotinic acid, molecular formula is C12H8FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 261A (4-{[6-Fluorophenyl)-pyridine-3-carbonyl]amino}cyclohexyl)acetic acid methyl ester 6-(3-Fluorophenyl)nicotinic acid (Preparation 1 , 154mg, 0.71 mmol), 1-hydroxybenzotriazole (1 18mg, 0.771 mmol), EDC (148mg, 0.77mmol) and DIEA (0.68mL, 4.14mmol) were added to a solution of (4-aminocyclohexyl)acetic acid methyl ester hydrochloride (166mg, 0.592mmol) in DCM (3 ml) and the mixture was stirred at room temperature for 18 hours. The reaction mixture was partitioned between brine (10 ml.) and DCM 1 (OmL) and the organic phase was separated, washed with brine (5×10 ml_), dried over MgSO4 and concentrated in vacuo. The crude product was washed with acetonitrile and filtered to give 218mg of title compound as a white powder.LRMS: m/z (ES+) [M+1] 371.1H NMR(400MHz, CDCI3): delta ppm 1.18(m, 2H), 1.30(m, 2H),1/71 (m, 1 H), 1.85(m, 2H), 2.15(m, 2H), 2.25(d, 2H), 3.68(s, 3H), 3.96(m, 1 H), 5.98(d, 1 H), 7.15(m, 1 H), 7.44(m, 1 H), 7.78(m, 3H), 8.16(m, 1 H), 9.00(m, 1 H).
According to the analysis of related databases, 582325-22-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; WO2009/153720; (2009); A1;,
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