Application of 1187322-51-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile. A new synthetic method of this compound is introduced below.
To the degassed mixture of 6-amino-5-(prop-l -yn-l-yl)pyridine-3-carbonitrile (329 mg, 1.34 mmol), bis'(triphenylphosphine)dichloropailadium(0) (95 mg, 0.134 mmol), copper (I) iodide (128 mg, 0.671 mmol) and triethylamine (976 mg, 1.34 mL, 9.64 mmol) in ahs. THF (18 mL) a propyn solution (3-4 % in THF; 13.2 mL) was added via septum at 0-5 C. The mixture was stirred for 30 minutes at 0-5 C, then for a further 18 hours at room temperature. The reaction was quenched by the addition of NFLCl solution. The solid was removed by filtration and the cake was washed with CH2CI2. The combined organic layer was dried with anhydrous NaiSOr, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica, eluted by 40 % EtOAc in cyclohexane to give 150 mg of the title compound as a yellow solid (71 %).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1187322-51-5, 6-Amino-5-iodonicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; RICHTER GEDEON NYRT.; ELES, Janos; DUDASNE MOLNAR, Katalin; LEDNECZKI, Istvan; TAPOLCSANYI, Pal; HORVATH, Anita; NEMETHY, Zsolt; LEVAY, Gyoergy Istvan; (0 pag.)WO2020/12422; (2020); A1;,
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