Adding a certain compound to certain chemical reactions, such as: 824-51-1, 6-Methyl-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 824-51-1, blongs to pyridine-derivatives compound. Recommanded Product: 6-Methyl-1H-pyrrolo[2,3-b]pyridine
A mixture of 5-bromoJ-inethyI-2-((2(trimethylsiiyi)ethoxy)methyi)-2H4ndazole(Intennectiate 13, 0.25 rnL, 0.76 rnmoi), 6-methyF-1Hpyrrolo2,3-b]pyridine (100mg, 076 rnrnoi), IPd(ll) cinnamy1)Cl]2 (24 mg, 0.045 mmol), BippyPhos (47 mg, 0091 mmol), and sodium tertbutoxide (105 mg, 1 06 mmoi) in I ,4-dioxane (5 mL) was heated in a microwave reactor at 180 C for 2.0 minutes. The reaction mixture was diluted with 1-120 and extracted with EtOAc (5 mL x 3). The organic layer was dried (Na2SO4) and concentrated in vaeuo. Purification FCC, Si02, 0:100 to20:80. EtOAc:Hex) afforded the title compound (251 rng, 85%). MS (ESI): mass calcd. for C22H28NOSi, 392.2; mz found, 393.2 [M+Hi.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-51-1, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
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