With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.832715-99-8, name is 6-(tert-Butyl)nicotinic acid, molecular formula is C10H13NO2, molecular weight is 179.22, as common compound, the synthetic route is as follows.SDS of cas: 832715-99-8
A solution of 6-(tert-butyl)nicotinic acid (1 , 1 .8 g, 10.05 mmol) in thionyl chloride (20 mL) was heated at 70 C for 3 h. The reaction mixture evaporated completely and dried to afford the title compound 6-(tert-butyl)nicotinoyl chloride (2, 1.8 g, crude) as a brownish liquid. The crude product was as such taken to next step without any purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,832715-99-8, 6-(tert-Butyl)nicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; CADENT THERAPEUTICS; ANDERSON, David, R.; VOLKMANN, Robert, A.; MENNITI, Frank; FANGER, Christopher; XU, Yuelian; (252 pag.)WO2018/119374; (2018); A1;,
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