Adding a certain compound to certain chemical reactions, such as: 62774-90-7, 2,6-Dichloro-4-methylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 62774-90-7, blongs to pyridine-derivatives compound. Product Details of 62774-90-7
2,6-Dichloro-4-methyl-nicotinic acid (0.234 g, 1.14 mmol) and hydrogen peroxide- urea adduct (0.537 g, 5.70 mmol) were suspended in CH2Cl2 to give a white slurry. Trifluoroacetic anhydride (0.65 ml, 4.67 mmol) was added dropwise over 5 minutes and the resulting pale yellow solution was stirred overnight at rt. The reaction mixture was quenched with water (10 ml) and then dry loaded onto silica gel and purified using column chromatography (MeCN/MeOH/NH4OH, 8:1:1, v/v/v) to give 2,6-dichloro-4-methyl-nicotinic acid-iV-oxide as a pale yellow crystalline solid (0.103 g, 41 %). 1H NMR (CD3OD ) delta 2.37 (s, 3H), 7.60 (s, IH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,62774-90-7, 2,6-Dichloro-4-methylnicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem