Reference of 63071-13-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.63071-13-6, name is 4-Chloropicolinaldehyde, molecular formula is C6H4ClNO, molecular weight is 141.56, as common compound, the synthetic route is as follows.
A mixture of A-i (1.5 g, 10.6 mmol) and 4-methylbenzene- sulfonohydrazide (1.97 g, 10.6 mmol) in methanol (15 mL) was stirred at 20C for 3 hours.The solid was collected by filtration, washed with MeOH (3 mL), and dried in oven to afford A-2 (2400 mg, 7.75 mmol) as a solid. ?H NMR (400MHz, DMSO-d6) oH = 11.96 (s, 1H), 8.53 (d, 1H), 7.90 (s, 1H), 7.78 (d, 2H), 7.71 (d, JH), 7.53 (dd, IH), 7.43 (d, 2H), 2.37 (s, 3H).
The chemical industry reduces the impact on the environment during synthesis 63071-13-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (120 pag.)WO2019/35951; (2019); A1;,
Pyridine – Wikipedia,
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