Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6313-54-8, name is 2-Chloroisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H4ClNO2
To a solution of 2-chloroisonicotinic acid (3.08 g) in dichloromethane (60 mL) were added WSC/HCl (5.62 g), HOBt (4.5 g), N,O-dimethylhydroxyamine hydrochloride (2.9 g) and triethylamine (8.3 mL), and the mixture was stirred overnight. The reaction mixture was diluted with aqueous ammonium chloride solution, extracted with dichloromethane, dehydrated with sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=2/1) to give Compound II (3.51 g).
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Reference:
Patent; DAINIPPON SUMITOMO PHARMA CO., LTD.; US2012/225876; (2012); A1;,
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