The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 6419-36-9
To a solution of (S)-((3R,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl) 5,6-bis(nitrooxy)hexanoate (Example 1, Step 8) (100 mg, 0.273 mmol) in dry DCM (3 ml), DMAP (73 mg, 0.601 mmol), DCC (112 mg, 0.546 mmol) and 3-pyridylacetic acid hydrochloride (57 mg, 0.328 mmol) were added. The mixture was stirred overnight at room temperature, then DMAP (73 mg, 0.601 mmol) and 3-pyridylacetic acid hydrochloride (57 mg, 0.328 mmol) were added. The mixture was allowed to stir for 4 hours. The solid was filtered off, water and DCM were added, the two phases were separated and the aqueous phase extracted twice with DCM. The combined organic phases were dried over MgS04 and concentrated under reduced pressure. The residue was purified by reversed-phase chromatography (H20/CH3CN from 95:5 to 30:70), to give 58 mg of the desired product (yield: 43.8%). NMR (600 MHz, DMSO-d6) delta 8.49 – 8.46 (m, 2Eta), 7.72 – 7.68 (m, IH), 7.38 – 7.34 (m, IH), 5.45 – 5.40 (m, IH), 5.05 (q, IH), 4.97 (q, IH), 4.93 (dd, IH), 4.71 (dd, IH), 4.64 – 4.58 (m, 2H), 3.92 (dd, IH), 3.87 (dd, IH), 3.79 (s, 2H), 3.68 (dd, IH), 3.56 (dd, IH), 2.41 (t, 2H), 1.80 – 1.72 (m, 2H), 1.68 – 1.60 (m, 2H).
Statistics shows that 6419-36-9 is playing an increasingly important role. we look forward to future research findings about 2-(Pyridin-3-yl)acetic acid hydrochloride.
Reference:
Patent; NICOX S.A.; ALMIRANTE, Nicoletta; BRAMBILLA, Stefania; STORONI, Laura; BASTIA, Elena; (47 pag.)WO2018/224419; (2018); A1;,
Pyridine – Wikipedia,
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