As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6602-32-0
EXAMPLES; Example 1; 2-Bromo-3-hydroxy-6-iodopyridine; To a mixture of 14g of 2-bromo-3-hydroxypyridine (80.5 mmol), and 22.3g of K2CO3 (161 mmol) in 180 mL of water at room temperature was added 21. 0g of 12 (82. 7 mmol) in one portion. The mixture was stirred at room temperature for 2h then carefully neutralized with 3N HC1 (aq) to pH = 6. The solid was collected by vacuum filtration and washed with water (100 mL), 2M aqueous sodium bisulfite (50 mL), and water (100 mL). The solid was dried in vacuo to give 16. lg of 2-bromo-3-hydroxy-6-iodopyridine as a tan solid. IH NMR (300 MHz, MeOD) 5 7.57 (d, J=8.3Hz, 1H), 6.95 (d, J=8.3Hz, 1H).
With the rapid development of chemical substances, we look forward to future research findings about 6602-32-0.
Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2005/61458; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem