Reference of 66572-56-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66572-56-3, name is 2-Bromoisonicotinic acid. A new synthetic method of this compound is introduced below.
HATU (45.17 g, 118.81 mmol) was added to a mixture of 2-bromopyridine-4- carboxylic acid (20 g, 99.01 mmol), DIPEA (69 mL, 396.03 mmol), and DMF (150 mL) at rt. The mixture was stirred for 45 min, and then 2-methylpropanamidine hydrochloride (14.57 g, 118.8 mmol) was added. The mixture was stirred for 3 h, poured into H20 (2 L), and then extracted with EtOAc (500 mL c 3). The combined organic layers were dried over Na2S04, filtered, concentrated, and then purified by silica gel chromatography (petroleum ether/EtOAc = 1/1) to give 2-brom o-N-( 1 -i m i no-2-m ethyl propyl )i soni coti nam i de (9 g, 34%) as a white solid. LCMS: 270.0 [M+H]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66572-56-3, its application will become more common.
Reference:
Patent; METACRINE, INC.; SMITH, Nicholas D.; GOVEK, Steven P.; LAI, Andiliy G.; (0 pag.)WO2020/61118; (2020); A1;,
Pyridine – Wikipedia,
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