Application of 677728-92-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 677728-92-6 as follows.
A suspension of 6-fluoro-pyridine-3-carbaldehyde (125 mg, 1.0 mmol), N-[3-(3-fluoro-4-hydroxy-phenyl)-2-oxo-oxazolidin-5(S)-ylmethyl]- acetamide (200 mg, 0.746 mmol), K2CO3 (552 mg, 4.0 mmol) in acetonitrile (20 niL) was stirred at 60 C under nitrogen for 15 h. The reaction mixture was diluted with EtOAc, filtered and evaporated. The crude product was purified by flash chromatography (1 : 1 hexane/EtOAc followed by 1 % MeOH in EtOAc) to give the title product as oil (235 mg, 84 %). ESI MS m/z 31 A (M + H+); 1H NMR (400 MHz, CD3OD) delta 9.97 (s, 1 H), 8.60 (d, J= 2.0 Hz, 1 H), 8.29 (dd, J= 8.4, 2.4 Hz, 1 H), 7.70 (dd, J= 12.0, 1.6 Hz, 1 H), 7.33-7.20 (m, 3 H), 4.80-4.78 (m, 1 H), 4.19 (t, J= 9.0 Hz, 1 H), 3.85 (dd, J= 9.6, 6.4 Hz, 1 H), 3.58 (d, J= 4.8 Hz, 2 H), 1.97 (s, 3 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,677728-92-6, its application will become more common.
Reference:
Patent; GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT; WO2009/120789; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem