Reference of 74115-12-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74115-12-1, name is 5-Chloro-3-hydroxypyridine, molecular formula is C5H4ClNO, molecular weight is 129.5444, as common compound, the synthetic route is as follows.
To a solution of 5-chloropyridin-3-ol (6f) (1.30 g, 10.0 mmol) in THF (50 mL) was added Et3N (1.21 g, 12.0 mmol) and 1,1,1-trifluoro-N-phenyl-N-[(trifluoromethyl)sulfonyl]methanesulfonamide (3.93 g, 11.0 mmol) at room temperature. After stirring for 20 min, the solvent was removed under reduced pressure. The residue was partitioned between EtOAc and 1 mol/L HCl. The separated aqueous layer was extracted with EtOAc again. The combined extract was washed with brine, dried over anhydrous MgSO4, filtered, and then concentrated in vacuo. The residue was purified by silica gel column chromatography (n-hexane/EtOAc = 99/1-19/1) to afford compound 6a (1.73 g, 66%) as a colorless oil: 1H-NMR (CDCl3) d 7.69 (1H, t, J = 2.3 Hz), 8.52 (1H, d, J = 2.3 Hz), 8.64 (1H, d, J = 1.9 Hz).
Statistics shows that 74115-12-1 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-3-hydroxypyridine.
Reference:
Article; Nishida, Haruyuki; Fujimori, Ikuo; Arikawa, Yasuyoshi; Hirase, Keizo; Ono, Koji; Nakai, Kazuo; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Fujioka, Yasushi; Imanishi, Akio; Fukui, Hideo; Itoh, Fumio; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3447 – 3460;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem