Related Products of 75291-85-9 ,Some common heterocyclic compound, 75291-85-9, molecular formula is C6H4BrClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation 119tert-butyl (3R,4S)-4-[(5-bromo-3-carbamoylpyridin-2-yl)oxyl-3-fluoropiperidine- 1 -carboxylate A solution of 5-bromo-2-chloronicotinamide (Preparation 177, 11.7 g, 49.8 mmol), tert-butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1 -carboxylate (WO 20131011402 Al, 10.9 g, 49.8 mmol) and potassium tert-butoxide (6.72 g, 60 mmol) in DMSO (165 mL) was stirred at roomtemperature for 16 hours. The reaction was quenched by the addition of water (500 mL) and extracted into EtOAc (3 x 500 mL). The organic layers were combined, concentrated in vacuo and the residue triturated with diethylether to afford the title compound as a pale yellow powder(17.8 g, 85%).1H NMR (400 MHz, DMSO-d6): O ppm 1.39 (5, 9H), 1.82 (m, 1H), 1.94 (m, 1H), 3.01 (m, 1H),3.27 (m, 1H), 3.93 (5, 1H), 4.14 (5, 1H), 4.98 (d, 1H), 5.38 (dddd, 1H), 7.51 (5, 1H), 7.90 (5, 1H),8.26 (d, 1H), 8.41 (d, 1H). MS mlz 418 [M79Br-fH]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 75291-85-9, 5-Bromo-2-chloronicotinamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER LIMITED; SKERRATT, Sarah Elizabeth; BAGAL, Sharanjeet Kaur; SWAIN, Nigel Alan; OMOTO, Kiyoyuki; ANDREWS, Mark David; WO2015/92610; (2015); A1;,
Pyridine – Wikipedia,
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