Related Products of 79055-59-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 79055-59-7, name is 2-Bromo-6-methylpyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
Ethyl 4-[[(lR)-2,2-difluoro-l-methyl-propyl]sulfamoyl]-3-fluoro-l -methyl-pyrrole -2- carboxylate (250 mg, 0.73 mmol) and 2-bromo-6-methylpyridin-4-amine (163.91 mg, (0748) 0.88 mmol) in THF (3.91 mL, 0.89 g/mL, 48.32 mmol) was stirred at room temperature and then lithium bis(trimethylsilyl)amide in THF (2.19 mL, 1 M, 2.19 mmol) was added at once. (0749) The mixture was stirred for 1 hour and then quenched with NH4CI and extracted with EtOAc. The combined extracts were concentrated and the obtained crude was purified by silica gel column chromatography using gradient elution from heptane to EtOAc. (100:0 to 0: 100). The desired fractions were concentrated in vacuo and the obtained oil was crystallised out of iPrOH. The crystals were collected and dried in a vacuum oven at 55C yielding compound 157 (252 mg) of compound 157 as a white powder. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.07 (d, J=7.0 Hz, 3 H), 1.57 (t, J=19.1 Hz, 3 H), 2.41 (s, 3 H), 3.47 – 3.64 (m, 1 H), 3.80 (s, 3 H), 7.49 – 7.53 (m, 1 H), 7.55 (d, J=4.4 Hz, 1 H), 7.77 (br. s, 1 H), 8.22 (br. s., 1 H), 10.44 (br. s., 1 H). Method B: Rt: 1.00 min. m/z: 483.0 (M-H)~ Exact mass: 484.0.
According to the analysis of related databases, 79055-59-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; VANDYCK, Koen; HACHE, Geerwin Yvonne Paul; LAST, Stefaan Julien; ROMBOUTS, Geert; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2015/118057; (2015); A1;,
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