Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 800402-12-4, name is 2-Chloro-5-iodo-4-pyridinamine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-iodo-4-pyridinamine
2-(3-(4-Amino-6-chloropyridin-3-yl)prop-2-ynyl)-6-(thiophen-2- yl)pyridazin-3(2H)-one. A mixture o f Et3N (200 mul, 1435 mumol), Cu(I) (10 mg, 53 mumol), PdCl2(PhP3)2 (20 mg, 28 mumol), 2-(prop-2-ynyl)-6-(thiophen-2- yl)pyridazin-3(2H)-one (90 mg, 416 mumol), and 2-chloro-5-iodopyridin-4-amine (138 mg, 542 mumol) in MeCN (1.5 mL) was heated to 80 0C under nitrogen for 1 h. The mixture was cooled to room temperature, and was loaded to a silica column. Chromatography with 0.5-5% MeOH in CH2Cl2 afforded a pink solid which was triturated with EtOAc-hexane (1 :2, 10 mL) to give a pink solid as the pure product (48 mg). MS (ESI pos. ion) calc’d for Cj6Hi 1CIN4OS: 342.0; found 343.1 (MH+). 1H NMR (400 MHz, Chloroform-d) delta ppm 5.18 (s, 2 H) 5.75 (br. s., 2 H) 6.64 (s, 1 H) 7.03 (d, J=9.78 Hz, 1 H) 7.11 (dd, J=5.09, 3.72 Hz, 1 H) 7.37 – 7.48 (m, 2 H) 7.73 (d, J=9.78 Hz, 1 H) 8.03 (s, 1 H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 800402-12-4, 2-Chloro-5-iodo-4-pyridinamine.
Reference:
Patent; AMGEN INC.; WO2008/103277; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem