Synthetic Route of 832735-60-1 , The common heterocyclic compound, 832735-60-1, name is 7-Bromo-[1,2,4]triazolo[4,3-a]pyridine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To 7-bromo-[1,2,4]triazolo[4,3-a]pyridine (930.9 mg, 4.70 mmol)And benzophenone imine (1.70g, 9.38mmol)Toluene (40 mL) suspension was addedPd2(dba)3 (217.7 mg, 0.24 mmol), BINAP (293.4 mg, 0.45 mmol)And t-BuONa (908.4 mg, 9.45 mmol).The reaction system was stirred at 100 C overnight.After the reaction,The reaction was quenched by the addition of water (50 mL).The resulting mixture was extracted with EtOAc (100 mL×3).The combined organic phases were washed with brine (100 mL).Dry over anhydrous sodium sulfate,Filter and concentrate under reduced pressure.The residue obtained is purified by silica gel column chromatography (MeOH/DCM (v/v) = 1 / 20).The title compound was obtained as a brown solid (1.66 g, yield 46.3%).
The synthetic route of 832735-60-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyridine – Wikipedia,
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