Synthetic Route of 88511-27-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88511-27-7, name is 4-Amino-3-iodopyridine, molecular formula is C5H5IN2, molecular weight is 220.0111, as common compound, the synthetic route is as follows.
General procedure: In a typical experiment Pd(OAc)2 (5.6 mg, 0.025 mmol), triphenylphosphine (13.2 mg, 0.05 mmol), 4-amino-3-iodopyridine(1) (220 mg, 1.00 mmol), tert-butylamine (0.315 mL, 3.00 mmol)(or the given amount of primary or secondary amine (Table 1)) and triethylamine (0.5 mL) were dissolved in DMF (10 mL) under argon in a 100 mL autoclave. The atmosphere was changed to carbonmonoxide and pressurized to 40 bar. The reaction was conducted for the given reaction time upon stirring at 50C and analysed by TLC. The autoclave was vented, the reaction mixture was concen-trated and evaporated to dryness. The residue was dissolved in chloroform (20 mL) and washed with water (320 mL). The organic phase was dried over Na2SO4, filtered and evaporated to a solid material. All compounds were subjected to column chromatography ((Silicagel 60 (Merck), 0.063 e 0.200 mm); MeOH/CHCl3 orMeOH/EtOAc/CHCl3 (the exact ratios are specied in Characterization (4.4.) for each compound)).
Statistics shows that 88511-27-7 is playing an increasingly important role. we look forward to future research findings about 4-Amino-3-iodopyridine.
Reference:
Article; Szoke, Gyoengyi; Takacs, Attila; Berente, Zoltan; Petz, Andrea; Kollar, Laszlo; Tetrahedron; vol. 72; 22; (2016); p. 3063 – 3067;,
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