With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.886374-01-2, name is 5-Chloro-3-fluoro-2-methoxypyridine, molecular formula is C6H5ClFNO, molecular weight is 161.56, as common compound, the synthetic route is as follows.Recommanded Product: 886374-01-2
To a solution of compound 2 (3.6g, 17.56mmol, 1 eq) in Dry THF (20ml_), a solution of nBuLi (1.6M in hexane, 1 .5eq) was added dropwise over 10min at -78C and stirred 30min at the same temp. After, 30min crushed dry ice was added portion wise to the above solution at -78C. Then, the reaction mixture was allowed to warm up to RT over 2h. After 2h, the reaction mixture was cooled to 0C and neutralized by conc.HCI. Then, the reaction mixture was concentrates under reduced pressure to give a crude product. The crude product was dissolved in 5M NaOH solution and washed with ether; the aqueous layer was cooled to 0C and acidified to pH 5-6 by cone. HCI. A precipitate formed. The precipitate was filtered and washed with ether to give compound 3 (2.7g, 75.0%) as a white solid. LCMS: m/z 204.1 (M-1 )
At the same time, in my other blogs, there are other synthetic methods of this type of compound,886374-01-2, 5-Chloro-3-fluoro-2-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem