Reference of 889865-45-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 889865-45-6, name is 2,3-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Description 11; 3-Chloro-4-iodo-pyridin-2-ylamine (D11); A mixture of compound DlO (6 g, 21.9 mmol) in aqueous NH4OH (12 ml, 11 N) was heated at 129 0C for 12 h. After cooling to room temperature, DCM was added. The organic layer was separated, washed with brine, dried (Na2SO4) and evaporated in vacuo. The residue thus obtained was purified by column chromatography (silica gel; DCM/MeOH(NH3) up to 2% as eluent). The desired fractions were collected and evaporated in vacuo to yield compound DIl (2.88 g, 52%) as a white solid. LCMS: MW (theor): 254; [MH+]: 255; RT (min): 2.22. (Method 13)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 889865-45-6, 2,3-Dichloro-4-iodopyridine.
Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC.; ADDEX PHARMA S.A.; CID-NUNEZ, Jose, Maria; TRABANCO-SUAREZ, Andres, Avelino; MACDONALD, Gregor, James; WO2010/60589; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem