Related Products of 893423-62-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.893423-62-6, name is tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate, molecular formula is C11H13ClN2O3, molecular weight is 256.69, as common compound, the synthetic route is as follows.
To a solution of tert-butyl (2-chloro-3-formylpyridin-4-yl) carbamate (3-1, 30.5 g, 118.9 mmol) and l-[4-(l,3-dioxolan-2-yl)phenyl]-2-phenylethanone (3-2, 29.0 g, 108.1 mmol) in anhydrousTHF (300 mL) at room temperature was added LHMDS (IM in THF, 248 mL) in a stream. The reaction mixture was stirred at room temperature overnight and then it was refluxed for 24 hr. It was cooled and concentrated to a syrup and treated with NaHCO3 (saturated, 50 mL) and water (300 mL) to form a solid which was collected via filtration. The solid was dried, washed with ether and further dried with toluene azeotropically to give the title compound. LRMS m/z (M+1) Calcd: 389.1, found 389.1.
Statistics shows that 893423-62-6 is playing an increasingly important role. we look forward to future research findings about tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate.
Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
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