As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90610-06-3, name is Methyl 2-(6-methylpyridin-3-yl)acetate, molecular formula is C9H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Methyl 2-(6-methylpyridin-3-yl)acetate
To a stirred solution of methyl (6-methylpyridin-3-yl)acetate (60 mg, 0.36 mmol) in methanol (5 ml) was added NaOH (1.0 ml of a 2M aqueous solution, 2.0 mmol) and the resulting solution was heated at 65 0C for 2 hours. The solvent was then removed at reduced pressure and the resulting residue was dissolved in methanolic HCl (5 ml) and then reconcentrated to yield the title product (54 mg, quant, yield) that was used without further purification. LCMS data: Calculated MH+ (152); Found 100% (MH+) m/z 152, Rt = 0.79 min. Method C.
With the rapid development of chemical substances, we look forward to future research findings about 90610-06-3.
Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; DAVENPORT, Adam, James; HALLETT, David, James; STIMSON, Christopher, Charles; WO2010/86403; (2010); A1;,
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