Synthetic Route of 97944-43-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 97944-43-9, name is 3-Bromo-5-methylpyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 3-bromo-5-methylpyridine-4-amine (5.00 g, 27 mmol), (0231) isopropenylboronic acid pinacol ester (6.70 g, 40 mmol), Pd(PPh3)4 (3.20 g, 2.70 mmol), l,4-dioxane (50 mL), and NaHCCh (sat. aq., 50 mL) was stirred under reflux for 16 h. Then the suspension was cooled and diluted with water and DCM until clear phase separation. The aqueous phase was extracted with DCM. The combined organic extracts were dried (MgS04), filtered and concentrated under reduced pressure. The crude mixture was purified by flash column chromatography (silica, mobile phase gradient: 0-3% 7N NFT/McOH in DCM). The residue was combined with another fraction (1.5 g) and dissolved in z-PrOH (20 mL). The mixture was treated with HC1 (6M in z-PrOH, 9 mL, 54 mmol) and stirred over the weekend. The mixture was ice- cooled and the product was collected by filtration to afford 1-67 (4.5 g, 76%) as a white solid.
According to the analysis of related databases, 97944-43-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; LEENAERTS, Joseph, Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; MARTINEZ LAMENCA, Carolina; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (110 pag.)WO2019/243533; (2019); A1;,
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