Adding a certain compound to certain chemical reactions, such as: 89937-77-9, Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89937-77-9, blongs to pyridine-derivatives compound. Recommanded Product: 89937-77-9
LiH (78 mg) was suspended in DMF (5 ml), and a suspension of methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (500 mg) in DMF (5 ml) was added dropwise thereto at room temperature. The suspension was stirred as it was, and a solution of 1-indo-2-methylpropane (506 mul) in DMF (5 ml) was added dropwise thereto over 10 min, followed by stirring at 50C for 15 hours. To the reaction solution was added 1M HCl at 0C, followed by extraction with EtOAc, and the organic layer was washed with saturated brine, dried over anhydrous MgSO4, and filtered, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (n-hexane:EtOAc=90:10 to 50:50) to obtain methyl-1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylate (440 mg) as white powders.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89937-77-9, its application will become more common.
Reference:
Patent; Astellas Pharma Inc.; EP2003132; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem