Application of Methyl 2-aminonicotinate

According to the analysis of related databases, 14667-47-1, the application of this compound in the production field has become more and more popular.

Electric Literature of 14667-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14667-47-1, name is Methyl 2-aminonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Preparation of IVb : [0098] 2-aminonicotinic acid methyl ester (6. 4g, 42 MMOLE) was dissolved in chloroform (SOMA) treated with triethylamine (6. 25MOL, 45mmole) followed by dropwise addition of 3- CHLOROBENZOYL chloride (7. 8G, 45mmole) dissolved in 10MOL chloroform. The reaction mixture was stirred for 2 days at room temperature, washed reaction mixture with 10% sodium bicarbonate, 5% HCl, water. Dried chloroform layer over sodium sulfate (ANH), removed solvent to give an oil. Trituration with 30% ethyl acetate in hexanes gave the product as A solid, which was isolated by filtration to give 12. 4G product

According to the analysis of related databases, 14667-47-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SCIOS INC.; WO2005/32481; (2005); A2;,
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