Adding a certain compound to certain chemical reactions, such as: 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56026-36-9, blongs to pyridine-derivatives compound. Product Details of 56026-36-9
6-hydroxymethyl nicotinic acid methyl ester (11 ) (10.0 g, 59.8 mmol) was azeotroped with acetonitrile ( 2 x 100 mL) then dissolved in (0261) dichloromethane (alcohol free, 150 mL) and treated with (0262) diisopropylethylamine (12.5 mL, 71 .8 mmol) followed by 2-cyanoethyl-N,N- diisopropylchlorophosphoramidite (13.4g, 56.8 mmol). The reaction mixture was stirred at RT, under argon for 1 .5 hours. TLC (1 : 1 hexane: EtOAc, visualised by PMA/heat) showed reaction completion (SM Rf ~ 0.3, prod Rf ~ 0.5). (0263) The mixture was washed with sat. NaHC03(aq) (100 mL) and the layers were separated. The organic phase was washed with 100 mL sat. then dried over anhydrous sodium sulphate, filtered and concentrated in vacuo to give a brown oil. This was triturated with pentane (2 x 150 mL). (0264) The crude material was purified by flash column chromatography on pre- equilibrated silica gel (1 : 1 EtOAc : pentane + 1 % NEt3) eluting with 1 : 1 EtOAc : pentane, the crude product was loaded in DCM. Product containing fractions were selected by TLC and concentrated in vacuo to give a colourless oil. This was azeotroped with MeCN and dried on the freeze-drier overnight to give 12 (6.55g, 30%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.
Reference:
Patent; LINK TECHNOLOGIES LIMITED; MCGEOCH, Grant; MCKEEN, Catherine; OSNOWSKI, Andrew; WILSON, Jennifer; WO2015/132577; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem