Electric Literature of 56026-36-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.
Dissolving methyl 6-(hydroxymethyl)nicotinate in DCM (10 mL).Cool to 0 C,Triethylamine (2.43 g, 12 mmol) was added in sequenceAnd methanesulfonyl chloride (2.06 g, 18 mmol),Slowly warm to room temperature and react overnight.TLC monitors the reaction completely,Add saturated aqueous ammonium chloride solution (5 mL),Liquid separation,The aqueous phase was extracted with DCM (3¡Á10 mL).Combine the organic phase,Washed (2 ¡Á 5mL),Dry over anhydrous sodium sulfate,filter,Concentrated6-((((methylsulfonyl)oxy)methyl)methyl nicotinate(3.2g crude).
The chemical industry reduces the impact on the environment during synthesis 56026-36-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
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