Related Products of 7169-97-3 ,Some common heterocyclic compound, 7169-97-3, molecular formula is C7H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
N-(5-bromopyridin-2-yl)acetamide (4.30 g, 20 mmol), m-carboxyphenylboronic acid (3.66 g, 22 mmol) was added to a 250 ml pear-shaped bottle.Further, cesium carbonate (13.0 g, 40 mmol) and tetrakistriphenylphosphine palladium (1.2 g, 1 mmol) were successively added.To the above mixture was added 200 ml of acetonitrile/water (V: V = 3: 2). N2 protection,The oil bath was heated to 90 C for 48 h. After the reaction was completed, the reaction solution was cooled to room temperature and suction filtered.The filtrate was adjusted to pH 4 with 6 mol/L hydrochloric acid to precipitate a white solid.After suction filtration, the cake was vacuum dried to give the product 3.53 g, yield 69%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7169-97-3, its application will become more common.
Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (14 pag.)CN109824582; (2019); A;,
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