Related Products of 65-22-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. A new synthetic method of this compound is introduced below.
In a round bottom flask containing 7 mL methanol and 3 mL of DMF was added the diamine N2S2-4C¡¤2HCl (0.1 mmol; 0.038 g), pyridoxal hydrochloride (0.2 mmol; 0.041 g) and 60 muL of triethylamine. The resulting suspension was heated at 60 C with magnetic stirring and then was added nickel perchlorate (0.1 mmol; 0.036 g). The resulting mixture was stirred at 60 C for 45 min. After this period, the flask contents the solution was cooled to room temperature and filtered. Red crystals were collected after 4 days by slow evaporation of the solvent. Yield (crystals): 84%. Melting point: up 250 C. IR (KBr pellets cm-1): nu(O-Halcohol) 3362 s, nu(Caliphatic-H) 2929 w, nu(C = N) 1602 s, nu(C = O DMF) 1654 s, nu(C-S) 761 m,. Anal. Calc.: C, 54.67; H, 5.24; N, 9.11. Found: C, 54.60; H, 5.49; N, 8.98.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, and friends who are interested can also refer to it.
Reference:
Article; Fontana, Liniquer Andre; Stueker, Monica; Oliveira, Gelson Manzoni; Iglesias, Bernardo Almeida; Back, Davi Fernando; Inorganic Chemistry Communications; vol. 62; (2015); p. 55 – 59;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem