Formula: C7H7NOIn 2020 ,《Design, Sonosynthesis, Quantum-Chemical Calculations, and Evaluation of New Mono- and Bis-pyridine Dicarbonitriles as Antiproliferative Agents》 appeared in Chinese Journal of Chemistry. The author of the article were Arafa, Wael Abdelgayd Ahmed; Hussein, Modather F.. The article conveys some information:
A highly efficient, simple, and clean single-step sonosynthetic procedure was sophisticated for assembling new series of mono- and bis-pyridine dicarbonitriles from ketones, HCl, and tetracyanoethylene. The presented protocol was applicable for the preparation of a broad range of uniquely substituted pyridine dicarbonitriles and were superior in comparison with other previously reported methods. The antiproliferative impact of the newly synthesized derivatives were screened towards three representative cancer cell lines (MCF-7, A549, and HCT116). Most of the evaluated derivatives showed a moderate to excellent anti-proliferative activity towards the selected cell lines. Of these, compounds I, II, III and IV [R = 2-pyridyl, 4-pyridyl] showed both potent anticancer activity (IC50 < 10μM) and lower cytotoxic effect (IC50 > 58μM) on non-tumorigenic cells (MCF-10A and NCM460), suggesting their promising potential to be lead mols. for future antitumor drug discovery. The structure-activity relationships was discussed. Moreover, quantum chem. studies based on d. functional theory (DFT) of the synthesized compounds were investigated and found to be consistent with the in-vitro inhibitory activities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO) was used in this study.
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H7NO