Aramesh-Boroujeni, Zahra; Bordbar, Abdol-Khalegh; Khorasani-Motlagh, Mozhgan; Sattarinezhad, Elham; Fani, Najme; Noroozifar, Meissam published the artcile< Synthesis, characterization, and binding assessment with human serum albumin of three bipyridine lanthanide(III) complexes>, HPLC of Formula: 366-18-7, the main research area is bipyridine lanthanide complex HAS mol docking binding affinity; Bpy, 2,2′-bipyridine; BpyDy, bipyridine dysprosium(III); BpyLn, bipyridine lanthanide; BpyTb, bipyridine terbium(III); binding interaction; fluorescence spectroscopy; human serum albumin; lanthanide complex; molecular docking.
In this work, the terbium(III), dysprosium(III), and ytterbium(III) complexes containing 2, 2′-bipyridine (bpy) ligand have been synthesized and characterized using CHN elemental anal., FT-IR, UV-Vis and 1H-NMR techniques and their binding behavior with human serum albumin (HSA) was studied by UV-Vis, fluorescence and mol. docking examinations The exptl. data indicated that all three lanthanide complexes have high binding affinity to HSA with effective quenching of HSA fluorescence via static mechanism. The binding parameters, the type of interaction, the value of resonance energy transfer, and the binding distance between complexes and HSA were estimated from the anal. of fluorescence measurements and Forster theory. The thermodn. parameters suggested that van der Waals interactions and hydrogen bonds play an important role in the binding mechanism. While, the energy transfer from HSA mols. to all these complexes occurs with high probability, the order of binding constants (BpyTb > BpyDy > BpyYb) represents the importance of radius of Ln3+ ion in the complex-HSA interaction. The results of mol. docking calculation and competitive experiments assessed site 3 of HSA, located in subdomain IB, as the most probable binding site for these ligands and also indicated the microenvironment residues around the bound mentioned complexes. The computational results kept in good agreement with exptl. data.
Journal of Biomolecular Structure and Dynamics published new progress about Binding energy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.