Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Safety of 2-Ethynylpyridine, 1945-84-2, Name is 2-Ethynylpyridine, SMILES is C1=C(N=CC=C1)C#C, belongs to pyridine-derivatives compound. In a document, author is Wang, Ya-Nan, introduce the new discover.
A series of novel cell membrane fluorescent probes based on oxazolopyridine unit
Fluorescent cell membrane probes (1a-d) were designed from bioactive oxazolo [4,5-b]pyridine unit. The probes were connected by oxazolo [4,5-b]pyridine and benzofuran (1a), triphenyl (1b), coumarin (1c), diethylaminobenzene (1d), respectively, with a double bond. The optical properties of 1a-d with different solvents were tested, they had obvious solvatochromism in different polar solvents, Large stokes shifts (63-204 nm) and significant fluorescent enhancement in large multilamellar vesicles (MLV). After 6 h of continuous illumination, the remaining absorption of the probes was 81-97%. The cytotoxicity test indicated that the survival rate of HeLa and L929 cells was 94-119% after co-cultured with probes 1a-d for 6 h. Laser confocal experiments further illustrated that the probes could quickly (<1 min) combine with the cell membrane. Among them, probe 1a worked in the green channel, while probes 1b, 1c and 1d employed in the red channel. Moreover, the retention time of probes 1a and 1c on cell membrane was found to 2-3 h. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1945-84-2. Safety of 2-Ethynylpyridine.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem