On October 21, 2021, Arnold, Lee D.; Lopatin, Uri; Keung, Walter published a patent.Synthetic Route of 39919-70-5 The title of the patent was Preparation of peptidomimetics as inhibitors of cysteine proteases for treatment of viral infections including COVID-19. And the patent contained the following:
The invention is related to the preparation of broad spectrum, viral protease inhibitor compounds, e.g., I, comprising a warhead covalently bound to a 3CL protease inhibitor, wherein the inhibitor compound covalently binds to Cys on the protease, and wherein the inhibitor compound is active against multiple such as viruses caliciviruses, picornaviruses and coronaviruses. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Thus, I was prepared by Ugi reaction between pyridine-3-carbaldehyde, 4-tert-butylaniline, (2R,4S)-1-tert-butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid and isocyanocyclohexane followed by cleavage of the tert-butoxycarbonyl group in II and treatment with BrCN. Select compounds of the invention were evaluated for their antiviral activity against COVID-19 (nCoV-2019, SARS-CoV2) Mpro in an enzymic assay and against human coronavirus 229E and OC43 in the cytopathic effect assays. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Synthetic Route of 39919-70-5
The Article related to peptidomimetic preparation viral cysteine protease inhibitor viral infection treatment, cysteine protease inhibitor antiviral sarscov2 covid19 mpro peptidomimetic preparation, covid19 treatment peptidomimetic preparation and other aspects.Synthetic Route of 39919-70-5