In 2022,Arroyo Negrete, Missael Antonio; Wrobel, Kazimierz; Yanez Barrientos, Eunice; Corrales Escobosa, Alma Rosa; Enciso Donis, Israel; Wrobel, Katarzyna published an article in Talanta. The title of the article was 《Determination of chromium(III) picolinate in dietary supplements by flow injection – electrospray ionization – tandem mass spectrometry, using cobalt(II) picolinate as internal standard》.Application In Synthesis of Picolinic acid The author mentioned the following in the article:
In this work, a principle of flow injection anal. (FIA) was applied for sample introduction to an electrospray ionization – ion trap mass spectrometer (ESI-ITMS) with the aim to quantify chromium(III) picolinate (CrPic3) in com. supplements by multiple reaction monitoring, and using cobalt(II) picolinate as internal standard (IS). FIA system was operated with ammonium formate 10 mmol L-1 in methanol-water (1:1, volume/volume) as a carrier solution at a flow rate 200μL min-1; 100μL injections were performed in 2-min intervals. Setting ion transitions m/z 419 → 270 and 304 → 260 for the analyte and IS, resp., and 100 ms integration time, the method detection and quantification limits 12 ng g-1 and 40 ng g-1 of Cr (as CrPic3) in the air-dried powder. Acetonitrile extracts of the real-world samples presented varying from sample-to-sample chem. composition and IS efficiently compensated for ionization interferences. Mean results from triplicate anal. of four different supplements were obtained with relative standard deviation 0.1-4.0%, indicating acceptable precision. Trueness of the proposed FIA-ESI-ITMS/MS procedure was demonstrated by 95.8-108% percentage recoveries attained in the anal. of the CrPic3-spiked samples. For comparative purposes, total Cr was determined by ICP-MS. The quant. results obtained indicate the necessity of anal. control of Cr(III) supplements com. available and demonstrate that the proposed FIA-ESI-ITMS/MS procedure is well-suited for the determination of CrPic3 in such products. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid