Asante, Du-Bois published the artcileAnti-inflammatory, anti-nociceptive and antipyretic activity of young and old leaves of Vernonia amygdalina, SDS of cas: 21829-25-4, the main research area is Vernonia leaf anti inflammatory nociceptive antipyretic; Aspirin; Cold allodynia; Diclofenac; Edema; Mast cells; Paw withdrawal; Pyrexia; Vernonia amygdalina.
Both young and old leaves of Vernonia amygdalina (VA) are traditionally used to treat inflammation, pain and fever. However, the efficacy of young and old leaves for treating these ailments have not been compared till date. To ascertain the effect of young and old leaves of VA in managing inflammation, pain and fever. Both quant. and qual. phytochem. screening of ethanol extracts of young (EthYL) and old (EthOL) leaves of VA were performed. The anti-inflammatory activity of orally administered Et and EthOL (50-200 mg/kg) and Diclofenac (10 mg/kg) were evaluated in carrageenan-induced inflammation model in rats. Antipyretic activity of Et, EthOL and Aspirin (25 mg/kg) were assessed in the Baker’s yeast-induced pyrexia model. Anti-allodynic effect of both extracts were evaluated by inserting inflamed paws of rats in cold water. Antinociceptive property of the extracts were assessed using tail withdrawal and formalin-induced nociception test. Histopathol. examination of the paws was performed, in addition to formalin test to understand the possible mechanism of action of the extracts Neg. control rats received 2 mL/kg normal saline in all tests. The amount of flavonoids, alkaloids, tannins, and phenolics were significantly (p < 0.05) higher in EthOL than Et, while saponins were significantly higher (p < 0.05) in Et than EthOL. The antioxidant ability and total antioxidant capacity were significantly (p < 0.05) higher in Et than EthOL. However, this was significantly (p < 0.05) lower than the anti-oxidant activity of Ascorbic acid. A dose-dependent increase in anti-inflammatory, antipyretic and antinociceptive properties were observed in both Et and EthOL, similar to the standard drugs. Mast cell degranulation accompanied by vasodilatation and high leukocytosis were observed in the neg. control, but were markedly low in extract treated groups. Both extracts mediated their analgesic effect through opioidergic and nitric oxide pathways with Et addnl. implicating the muscarinic cholinergic system. Although both Et and EthOL alleviate inflammation, pyrexia and nociception, Et of VA was found to be more potent than EthOL. Biomedicine & Pharmacotherapy published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, SDS of cas: 21829-25-4.