On February 2, 2012, Austin, Joel Francis; Sharma, Lisa S.; Balog, James Aaron; Huang, Audris; Velaparthi, Upender; Darne, Chetan Padmakar; Saulnier, Mark George published a patent.Category: pyridine-derivatives The title of the patent was Preparation of sulfonamide compounds useful as CYP17 inhibitors. And the patent contained the following:
The title compounds I [ring A = II-IV (wherein X, Y and Q = N and/or CR6; U = N, NR8, and/or CH; W and Z = N and/or C; with the provisos); R1 = H, halo, OH, etc.; R2 = H, halo, alkyl; R3 = H, halo, alkyl, alkoxy; R4 = H, halo, alkyl, alkoxy, haloalkoxy; R5 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R6 = H, halo, CN, etc.; R7 = halo, CN, haloalkyl, etc.; R8 = H, alkyl, SO2Ph], useful in the treatment of conditions related to CYP17 enzyme, such as cancer, were prepared E.g., a multi-step synthesis of V, starting from 3-bromo-4-methylpyridine, was described. Exemplified compounds I showed human CYP17 SPA IC50 values of less than 1 μM (specific data given for representative compounds I). Pharmaceutical compositions comprising compound I were disclosed. The experimental process involved the reaction of 3,5-Dibromo-4-methoxypyridine(cas: 25813-24-5).Category: pyridine-derivatives
The Article related to sulfonamide preparation cytochrome p450 monooxygenase cyp17 inhibitor antitumor, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Category: pyridine-derivatives