Awasthi, Amardeep; Mukherjee, Anagh; Singh, Mandeep; Rathee, Garima; Vanka, Kumar; Chandra, Ramesh published the artcile< Highly efficient chemoselective N-tert butoxycarbonylation of aliphatic/aromatic/heterocyclic amines using diphenylglycoluril as organocatalyst>, Electric Literature of 3731-53-1, the main research area is tertiary butyl carbamate chemoselective preparation DFT; amine tertiary butyldicarbonate carbonylation diphenylglycoluril organocatalyst.
An efficient approach for the chemoselective synthesis of tertiary-butyl-carbamates I [R1 = Ph, 4-BrC6H4, PhCH2CH2, etc.; R2 = H; R1R2 = CH2CH2N(Ph)CH2CH2] via N-tert-butoxycarbonylation of a variety of amines using diphenylglycoluril as organocatalyst was described. For the first time, a plausible mechanism for the N-tert-butoxycarbonylation was proposed using d. functional theory (DFT) calculations supported by NMR studies. The reusability of the organocatalyst and observation of the desired N-Boc protected amines I being formed without the formation of side products like urea, oxazolidinone, isocyanate, and N, N-di-Boc derivatives made the present protocol desirable.
Tetrahedron published new progress about Alkoxycarbonylation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.