Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of 4-Bromo-2-fluoropyridine, 128071-98-7, Name is 4-Bromo-2-fluoropyridine, molecular formula is C5H3BrFN, belongs to pyridine-derivatives compound. In a document, author is Katuri, Jashuva V. P., introduce the new discover.
Method for the Preparation of N-protected beta-Cyano L-alanine Tertiary Butyl Esters
Here we report a simple, efficient and scalable one-pot procedure for the synthesis of N-protected beta-cyano L-alanine tertiary butyl esters from N-protected L-asparagines. Reaction of N-protected L-asparagines with 2.2 equivalents of (Boc)(2)O and catalytic amount of N,N-dimethylamino pyridine (DMAP) in tertiary butanol at room temperature resulted N-protected beta-cyano L-alanine tertiary butyl esters. We also synthesized N-protected beta-cyano L-alanines from the obtained crude N-protected beta-cyano L-alanine tertiary butyl esters without column chromatography on gram scale in good yields. Control experiments gave the corresponding nitrile acids over the tertiary butyl esters. Later, we synthesized nitrile containing dipeptides by coupling N-Boc-beta-cyano L-alanine 4 a with amino acid methyl ester hydrochlorides.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 128071-98-7. Application In Synthesis of 4-Bromo-2-fluoropyridine.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem