Synthetic Route of 5431-44-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5431-44-7, Name is 2,6-Pyridinedicarboxaldehyde, SMILES is O=CC1=NC(C=O)=CC=C1, belongs to pyridine-derivatives compound. In a article, author is Krake, Everaldo F., introduce new discover of the category.
Unprecedented Formation of 2-Chloro-5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 5-oxide via Oxidation-Chlorination Reaction Using Oxone: A Combination of Synthesis and 1D-2DNMR Studies
Ticlopidine hydrochloride (1 center dot HCl, Ticlid (TM)) is a prodrug that, through bioactivation by cytochrome P450 (CYP), interacts with the P2Y(12) receptor ADP inhibiting platelet aggregation. This prodrug mediated by a multistep biochemical process led to the formation of active metabolic intermediates. In this work, an eco-friendly and efficient protocol for the formation of 2-chloroticlopidine (2) using 1 center dot HCl and oxone in aqueous methanol media via an unprecedented formation of reactive thienopyridine intermediate 2-chloro-5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 5-oxide (4) was developed. The key to success of 4 is the oxidation of tertiary amines to N-oxides, followed by mono-chlorination at the 2-position of the thiophene ring by oxidation of the chloride counterion of this prodrug. In addition, we use the 1D and 2DNMR techniques as a tool to monitor reaction progress, and for assigning the signals of all compounds involved, especially for the novel thienopyridine 4.
Synthetic Route of 5431-44-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5431-44-7.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem