Recently I am researching about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; ANTIMICROBIAL ACTIVITIES; EFFICIENT; CA9.5MG0.5(PO4)(5.5)(SIO4)(0.5)F-1.5; ANTICONVULSANT; COMBINATORIAL; SCAFFOLDS; CHEMISTRY; REAGENTS, Saw an article supported by the Islamic Azad University, Khorasgan, and Fasa BranchesIslamic Azad University. Recommanded Product: 500-22-1. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Memar, FO; Khazdooz, L; Zarei, A; Abbaspourrad, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
In this study, we synthesize 2-amino-4-alkyl/aryl-6-(hydroxymethyl)-8-oxopyrano[3,2-b] pyran-3-carbonitriles derivatives using a multicomponent reaction featuring aromatic or aliphatic aldehydes, kojic acid, and malononitrile catalyzed by nano fluoroapatite doped with Si and Mg (Si-Mg-FA). All reactions were carried out in EtOH as the solvent under reflux and green condition. The process demonstrates various advantages, including high yields, short reaction times, and simple workup. In addition, toxic organic solvent is not used, nor is chromatographic purification of products required. We characterized the synthesized compounds by Fourier transform infrared,(CNMR)-C-13, and(1)HNMR spectroscopies. Additionally, the antibacterial properties of the pyrano[3,2-b]pyran derivatives were evaluated by determining the minimum inhibitory concentration on two gram-positive and gram-negative bacteria using the macro dilution method and compared with Penicillin and Tetracycline at the same conditions. The 2-amino-4-(2,4-dichlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile and the 2-amino-4-hexyl-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile show the best antibacterial activity with a MIC value of 62.5 mu g/ml againstStaphylococcus aureus(ATCC 25923). Moreover, the antioxidant properties of the pyrano[3,2-b] pyrans derivatives were evaluated. It is notable that pyrano[3,2-b] pyrans derivatives, synthesized with substituent groups on benzaldehyde such as-NO2, -COOCH3, -OMe show the best antioxidant activity measured by DPPH radical-scavenging method.
Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Memar, FO; Khazdooz, L; Zarei, A; Abbaspourrad, A or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem