Name: 3-Pyridinecarboxaldehyde. Recently I am researching about ALZHEIMERS-DISEASE; GSK-3 INHIBITORS; DESIGN; CANCER; GENE; COMBINATION; INDIRUBINS; METABOLISM; SIMULATION; EFFICIENT, Saw an article supported by the Russian Foundation for Basic Research (RFBR), RussiaRussian Foundation for Basic Research (RFBR) [17-03-01320]; Council on grants of the President of the Russian Federation [SP-595.2018.4]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
Glycogen synthase kinase 3 beta (GSK-3 beta) is a widely investigated molecular target for numerous diseases including Alzheimer’s disease, cancer, and diabetes mellitus. Inhibition of GSK-3 beta activity has become an attractive approach for treatment of diabetes and cancer. We report the discovery of novel GSK-3 beta inhibitors of 3-arylidene-2-oxindole scaffold with promising activity. The most potent compound 3a inhibits GSK-3 beta with IC(50 )4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 mu M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.
Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem