Biological insights into the piericidin family of microbial metabolites was written by Azad, Sepideh. M.;Jin, Yu;Ser, Hooi-Leng;Goh, Bey-Hing;Lee, Learn-Han;Thawai, Chitti;He, Ya-Wen. And the article was included in Journal of Applied Microbiology in 2022.Application In Synthesis of Pyridin-4-ol This article mentions the following:
Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumor cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This studied the latest research progress of piericidins, covering the chem. structure and phys. properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this aimed to provide clues for the development of either new potential antibiotics or anti-tumor agents. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of Pyridin-4-ol