Bag, Sukdev; Jana, Sadhan; Pradhan, Sukumar; Bhowmick, Suman; Goswami, Nupur; Sinha, Soumya Kumar; Maiti, Debabrata published their research in Nature Communications in 2021. The article was titled 《Imine as a linchpin approach for meta-C-H functionalization》.Reference of 5-Bromo-2-chloropyridine The article contains the following contents:
An temporary directing group (TDG) for meta-C-H functionalization via reversible imine formation were reported. By overruling facile ortho-C-H bond activation by imine-N atom, a suitably designed pyrimidine-based TDG successfully delivered selective meta-C-C bond formation. Application of this temporary directing group strategy for streamlining the synthesis of complex organic mols. without any necessary pre-functionalization at the meta position were explored.5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 5-Bromo-2-chloropyridine