On December 31, 2011, Balhara, Yatan Pal Singh; Jain, Raka; Dhawan, Anju; Mehta, Manju published an article.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment. And the article contained the following:
Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiol. and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) – 2 mL, Pheniramine maleate – 45.5 mg, Lorazepam – 2 mg. The assessments were made at base line and then at 15 min, 120 min and 240 min. The subjects were assessed for the socio-demog. profile, drug use history, physiol. parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Anal. Used: Anal. was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiol. and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiol. and cognitive/psychomotor task performance. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate
The Article related to pheniramine maleate lorazepam cognition psychomotor impairment drug addiction, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate